P-Bromo Fluoro Benzene

AD PHARMACHEM is known for manufacturer of P-Bromo Fluoro Benzene intermediates.

 

 P-Bromo Fluoro Benzene is an organic compound that belongs to the class of aromatic halogenated hydrocarbons. It consists of a benzene ring substituted with both a bromine atom and a fluorine atom, positioned in a para configuration relative to each other (i.e., on opposite sides of the benzene ring). This compound is of interest in organic synthesis and chemical research due to its unique reactivity profile, influenced by the presence of two different halogen atoms.
 
P-Bromo Fluoro Benzene can serve as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other complex organic molecules. The bromine and fluorine atoms in the compound contribute to its ability to participate in a range of chemical reactions, such as cross-coupling reactions, where these halogen substituents can be replaced with other functional groups, leading to the formation of new chemical bonds and structures.

 

Physical and chemical properties of P-Bromo Fluoro Benzene

1.  Appearance : A clear colourless to pale yellow liquid.

2. Miscibility : Miscible with methanol and THF

 

3. Identification (By GC) : The retention time of the major peak in sample chromatogram is same as that of standard in purity by GC.

 

4. Moisture content (%w/v) : NMT 0.10

 

5. Specific gravity : Between 1.57-1.63

 

6. Chromatographic Purity by GC % area normalization

 

  • % Purity : NLT 99.50
  • % Fluorobenzene : NMT 0.10
  • % 1-Bromo-2-Fluorobenzene : NMT 0.10
  • % Individual impurities : NMT 0.10
  • % Total impurities : NMT 0.50
P-Bromo Fluoro Benzene

Application of P-Bromo Fluoro Benzene

 1. Organic Synthesis: It is widely used as an intermediate in the synthesis of complex organic compounds. The bromine and fluorine atoms make it a versatile reagent in reactions like Suzuki coupling, which is essential for creating new carbon-carbon bonds in organic chemistry.

2. Pharmaceuticals: This compound serves as a building block in the production of pharmaceutical drugs. Its ability to participate in various chemical reactions allows for the creation of active pharmaceutical ingredients (APIs) with specific therapeutic properties.

 

3. Agrochemicals: P-Bromo Fluoro Benzene is also utilized in the development of agrochemicals, such as pesticides and herbicides. Its chemical structure can be modified to create compounds that are effective in protecting crops from pests and diseases.

 

4. Material Science: In the field of material science, this compound is used in the production of advanced materials, including specialized polymers and coatings. The presence of both bromine and fluorine can enhance the durability, resistance, and performance of these materials.

 

5. Chemical Research: P-Bromo Fluoro Benzene is often used in research laboratories to study the effects of halogen substitution on the reactivity and properties of aromatic compounds. It serves as a model compound in various experimental studies aimed at understanding the behavior of halogenated benzenes.