Methyl Tri Phenyl Phosphonium Bromide (MTPPBr)
Methyl tri phenyl phosphonium bromide is an organophosphorus compound characterized by a phosphorus atom bonded to three phenyl groups and one methyl group, accompanied by a bromide ion. It is primarily used in organic synthesis, particularly in the Wittig reaction, where it serves as a reagent for the formation of alkenes from aldehydes and ketones.
- Chemical Formula: C19H18BrP
- Molecular Weight: 357.23 g/mol
- CAS Number: 1779-49-3
Physical and Chemical Properties Methyl tri phenyl phosphonium Bromide
1. Appearance: White to off-white crystalline powder.
2. Identification test for Bromide: Should respond to test for bromide
3. Loss on drying (%w/w) (105°C for 3 Hrs): NMT 1.0%
4. Ash (% w/w): NMT 0.5%
5. Triphenyl phosphine and triphenyl phosphonium content by Titrimetry (%w/w): NMT 1.5%
6. Assay by titrimetry (% w/w, on dried basis): NLT 99.0%
Application of Methyl tri phenyl phosphonium bromide
1. Wittig Reactions:
Methyl tri phenyl phosphonium bromide is extensively used in Wittig reactions, which are essential in the synthesis of alkenes from aldehydes and ketones. This reaction is vital for the production of complex organic molecules, including pharmaceuticals and fine chemicals.
2. Organic Synthesis:
Besides its role in Wittig reactions, this compound is used in various other organic transformations where phosphonium ylides are necessary intermediates for forming carbon-carbon bonds.
3. Pharmaceutical Industry:
The compound is employed in the pharmaceutical industry for the synthesis of drug intermediates and active pharmaceutical ingredients (APIs) that require the formation of alkenes or other complex molecular structures.
4. Chemical Industry:
Methyl tri phenyl phosphonium bromide is also utilized in the manufacture of specialty chemicals, where it serves as a reagent in reactions that involve the creation of new carbon-carbon bonds or the modification of existing molecular frameworks.